Nucleus for Change proposes a paradigmatic shift of the Western epistemic thought by understanding the slum as nucleus for knowledge production rather than a marginal place settled down on the peripheries of metropolitan cities. This new perception considers the slum as a central source of knowledge and cultural heritage for humanity. The research begins with studies on decolonial epistemologies from the Global South perspective and it continues with ongoing artistic explorations, such as participatory performances on-site. This project attempt to de-link1 our thinking process from Western Modernity and highlight the cultural identity of the marginal neighborhood as a decolonial action. The main methodology for this work is the notion of Multipolarity2—a way of thinking and doing that comes from the concept of “Sumak Kawsay” (or “Living Well”)3—a term borrowed from Andean’ Indigenous cultures in South America. Nucleus for Change tends to make visible the favela’s cultural background through the act of re-existence4 at the margins as autonomous centers of knowledge production. Here, the term re-existence offers an alternative to the use of the term resistance by seeking to carry out an action from the margin towards the center. Significantly, this process of re-existence creates a new form of integration and autonomy of the peripheries by revaluing people’s local cultures. Nucleus for Change does not attempt to reinforce the resistance but to rather to reinstate the relevance the local culture through the act of re-existence. For this ongoing project, re-existence will be achieved by attributing new values to the sub-culture of the neighborhood, and in doing so, reinforcing its strengths as a community through artistic explorations on-site. Consequently, different types of participatory performances will be organized in collaboration with inhabitants and then presents under the name Nucleus for Change.